miREA - Network-Based Edge-Centric MicroRNA-Oriented Enrichment Analysis

miREA performs microRNA-oriented enrichment analysis by modeling miRNA-gene interaction (MGI) networks directly, rather than collapsing them to miRNA- or gene-level sets. It implements four node-based methods and five edge-based methods spanning over-representation, scoring-based, topology-aware, and network-propagation approaches, using expression-informed MGI edge scores to characterize regulatory strength. The package also provides heatmap, Sankey, and summary visualizations to explore miRNA-gene-pathway regulatory mechanisms discovered by the enrichment results.